PARACRINE INDUCTION OF EPITHELIAL-MESENCHYMAL TRANSITION BETWEEN COLORECTAL CANCER CELLS AND ITS SUPPRESSION BY A P53/MIR-192/215/NID1 AXISSUMMARY

Paracrine Induction of Epithelial-Mesenchymal Transition Between Colorectal Cancer Cells and its Suppression by a p53/miR-192/215/NID1 AxisSummary

Background & Aims: Intratumor heterogeneity is a common feature of colorectal cancer (CRC).Here, we analyzed whether mesenchymal-like CRC cells promote the progression Cleansing Milk of epithelial-like CRC cells via paracrine mechanisms.Methods: Six CRC cell lines that show an epithelial phenotype were treated with conditioned media (CM) from CRC c

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Dual career in the workplace: co-creation of a conceptual framework by employers and employee-sportspersons incorporating corporate social responsibility and brand alignment

IntroductionThe purpose of this study was to provide an evidence base and conceptual framework to inform new guidelines for achieving a balance between Cologne sports and employment commitments (i.e., dual career, DC) of the employee-sportspersons.To shape a DC discourse in the workplace, the distinct and combined views of the employee-sportsperson

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Psychological consequences of lockdown on dental professionals during the early phase of the COVID-19 pandemic

BACKGROUND: Severe acute respiratory syndrome coronavirus 2, the virus that causes COVID-19, mainly spreads through respiratory droplets.The dental profession is particularly at risk.Routine dental care was suspended after the announcement of the first lockdown in India.This makes the group vulnerable to psychosocial consequences.The present study

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Novel immune scoring dynamic nomograms based on B7-H3, B7-H4, and HHLA2: Potential prediction in survival and immunotherapeutic efficacy for gallbladder cancer

BackgroundGallbladder cancer (GBC) is a mortal malignancy with limited therapeutic strategies.We aimed to develop novel immune scoring systems focusing on B7-H3, B7-H4, and HHLA2.We further investigated their potential clinical effects in predicting survival and immunotherapeutic efficacy for GBC.MethodsThis was a retrospective cohort study in a si

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